• A generally well-tolerated treatment option with 4% or fewer of patients experiencing application-site reactions in clinical trials1
  • Proven reductions in inflammatory and comedonal lesions1
  • Once-daily dosing that offers ease of use for patients who want to avoid complicated treatment regimens1
  • Flexibility that allows application any time of day1
  • Sodium hyaluronate, glycerin, and soluble collagen, which provide hydrating benefits1,3,4
  • An elegant lotion vehicle that disappears quickly into the skin, making it ideal for using under makeup2

Patients using ALTRENO may experience application site dryness, pain, erythema, irritation, and exfoliation.



ALTRENO™ (tretinoin) lotion, 0.05% is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.


ALTRENO is for topical use only. Not for ophthalmic, oral, or intravaginal use.

Skin Irritation: Patients using ALTRENO may experience application site dryness, pain, erythema, irritation, and exfoliation. Depending upon the severity of these adverse reactions, instruct patients to use a moisturizer, reduce the frequency of the application of ALTRENO, or discontinue use. Avoid application of ALTRENO to eczematous or sunburned skin.

Ultraviolet Light and Environmental Exposure: Minimize unprotected exposure to ultraviolet light, including sunlight and sunlamps. Warn patients with frequent sun exposure and those with inherent sensitivity to sunlight to exercise caution. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.

Fish Allergies: ALTRENO contains soluble fish proteins. Use with caution in patients with known sensitivity or allergy to fish. Advise patients to contact their healthcare provider if they develop pruritus or urticaria.

Adverse Reactions: The most common adverse reactions in clinical trials were application site dryness (4%), pain (3%), erythema (2%), irritation (1%) and exfoliation (1%).

Nursing Women: It is not known whether topical administration of tretinoin could result in sufficient systemic absorption to produce detectable concentrations in human milk. The developmental health benefits of breastfeeding should be considered along with the mother’s clinical need for ALTRENO and any potential adverse effects on the breastfed child from ALTRENO.

To report SUSPECTED ADVERSE REACTIONS, contact Customer Service at 1-800-321-4576 or the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.


  • Altreno lotion [package insert]. Bridgewater, NJ: Ortho Dermatologics.
  • Data on file. Ortho Dermatologics.
  • Dermatologists’ top tips for relieving dry skin. American Academy of Dermatology website. https://www.aad.org/public/skin-hair-nails/skin-care/dry-skin. Accessed December 11, 2018.
  • Morganti P, Randazzo SD, Cardillo A. Role of insoluble and soluble collagen as skin moisturizer. J Appl Cosmetol. 1986;4:141-152.