Ortho Dermatologics | Altreno (Tretinoin) Lotion, 0.05%

The new 20g size is now available for only $60. Prescribe today.

Patient Brochure

Altreno named a top skincare product of 2020 by Shape Magazine!

An expert panel of dermatologists and editors reviewed hundreds of skincare products, and Altreno was a winner!

Proven
inflammatory
lesion reductions

See Mean Reduction Data (%)

Primary Endpoints^1,2

Trial 1

The mean absolute reduction in inflammatory lesion counts with Altreno Lotion was 13.1 vs 10.2 for vehicle (P<0.001)
16.5% of patients experienced treatment success* vs 6.9% with vehicle (P<0.001)

Trial 2

The mean absolute reduction in inflammatory lesion counts with Altreno Lotion was 13.9 vs 10.7 for vehicle (P<0.001)
19.8% of patients experienced treatment success* vs 12.5% with vehicle (P=0.007)

*Treatment success was defined as at least a 2-grade improvement from baseline and an Evaluator’s Global Severity Score of clear (0) or almost clear (1). ²

See Mean Reduction Data (%)

Significant inflammatory lesion reductions at Week 12^1,2

Results of 2 phase 3, multicenter, randomized, double-blind, vehicle-controlled, parallel-group studies comparing the efficacy and safety of Altreno Lotion once daily for 12 weeks with vehicle in patients 9 years and older with moderate-to-severe acne vulgaris (baseline 20 to 40 inflammatory lesions). ^1,2

Proven
comedonal
lesion reductions

See Mean Reduction Data (%)

Primary Endpoints^1,2

Trial 1

The mean absolute reduction in comedonal lesion counts with Altreno lotion was 17.8 vs 10.6 for vehicle (P<0.001)
16.5% of patients experienced treatment success* vs 6.9% with vehicle (P<0.001)

Trial 2

The mean absolute reduction in comedonal lesion counts with Altreno lotion was 21.9 vs 13.9 for vehicle (P<0.001)
19.8% of patients experienced treatment success* vs 12.5% with vehicle (P=0.007)

*Treatment success was defined as at least a 2-grade improvement from baseline and an Evaluator’s Global Severity of clear (0) or almost clear (1). ²

See Mean Reduction Data (%)

Significant comedonal lesion reductions at week 12

Results of a phase 3, multicenter, randomized, double-blind, vehicle-controlled, parallel-group study comparing the efficacy and safety of Altreno lotion once daily for 12 weeks with vehicle in patients 9 years and older with moderate-to-severe acne vulgaris (baseline 20 to 100 comedonal lesions). ^1,2

Actual patients from Trial 1 after 12 weeks of once-daily Altreno Lotion treatment.

Baseline

Week 12

Photos have not been retouched. Individual results may vary.

A lotion formulated
with hydrating
ingredients for
your patients.

For greater comfort, the lotion has been enriched with ingredients proven to hydrate the skin^2-5 such as soluble collagen, glycerin and sodium hyaluronate (which is the sodium salt of hyaluronic acid and is valued as an excellent hydrating ingredient in topical skin care products³).

See what they said

“This product
absorbs quickly”

In a customer perception study of
15 women, 86% of them agreed.

Results from a customer perception study of patients using only the lotion vehicle. In this self-assessment, 15 women, aged 35-65, applied the vehicle lotion to the left side of their face, while leaving the other side untreated.

“I see an
improvement in skin
smoothness”

In a customer perception study of
15 women, 80% of them agreed.

Strong is the
new smooth

Clinical trials reported low incidence of adverse
reactions to Altreno Lotion.

View the tolerability data

Adverse events
reported in ≥1% of
patients and more
frequently than
Vehicle².

Patient benefits

Altreno Lotion can be applied at any time — day or night, once daily. It can even be worn under makeup.⁶ It’s ideal for active and successful women who favor premium products.

Over

97%

of physicians agreed that
the lotion vehicle:

Absorbs quickly and easily into the skin (99.7%)
Leaves no residue (98.3%)
Provides light-weight moisturization (97.1%)
Does not make my skin feel greasy (99.7%)
Has no unpleasant odor (98.6%)
Is not tacky to the touch (99.1%)

Results from a perception survey of healthcare professionals who tried the lotion vehicle. A total of 349 prescribers with practices in the U.S.A. tried the Altreno lotion vehicle and completed the survey.⁷

References

Data on file. Ortho Dermatologics.
Altreno Lotion [package insert]. Bridgewater, NJ: Ortho Dermatologics.
Wang Y, Viennet C, Jeudy A, Fanian F, He L, Humbert P. Assessment of the efficacy of a new complex antisensitive skin cream. J Cosmet Dermatol. 2018;17(6):1101-1107.
Dermatologists’ top tips for relieving dry skin. American Academy of Dermatology website. https://www.aad.org/public/skin-hair-nails/skin-care/dry-skin. Accessed March 20, 2020.
Morganti P, Randazzo SD, Cardillo A. Role of insoluble and soluble collagen as skin moisturizer. J Appl Cosmetol. 1986;4:141-152.
Data on File. A split-face, controlled clinical trial to evaluate the compatibility of an acne lotion with foundation makeup. 2019.
Data on File. Ortho Dermatologics. Perception survey: Healthcare professionals. 2019.

SEE MORE SEE LESS

INDICATIONS AND USAGE
Altreno (tretinoin) Lotion, 0.05% is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

IMPORTANT SAFETY INFORMATION
Altreno is for topical use only. Not for ophthalmic, oral, or intravaginal use.

Important safety information
Altreno is for topical use only. Not for ophthalmic, oral, or intravaginal use.

IMPORTANT SAFETY INFORMATION
Altreno is for topical use only. Not for ophthalmic, oral, or intravaginal use.

INDICATIONS AND USAGE
Altreno (tretinoin) Lotion, 0.05% is indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

IMPORTANT SAFETY INFORMATION
Altreno is for topical use only. Not for ophthalmic, oral, or intravaginal use.

Skin Irritation: Patients using Altreno may experience application site dryness, pain, erythema, irritation, and exfoliation. Depending upon the severity of these adverse reactions, instruct patients to use a moisturizer, reduce the frequency of the application of Altreno, or discontinue use. Avoid application of Altreno to eczematous or sunburned skin.

Ultraviolet Light and Environmental Exposure: Minimize unprotected exposure to ultraviolet light, including sunlight and sunlamps. Warn patients with frequent sun exposure and those with inherent sensitivity to sunlight to exercise caution. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.

Fish Allergies: Altreno contains soluble fish proteins. Use with caution in patients with known sensitivity or allergy to fish. Advise patients to contact their healthcare provider if they develop pruritus or urticaria.

Adverse Reactions: The most common adverse reactions in clinical trials were application site dryness (4%), pain (3%), erythema (2%), irritation (1%) and exfoliation (1%).

Nursing Women: It is not known whether topical administration of tretinoin could result in sufficient systemic absorption to produce detectable concentrations in human milk. The developmental health benefits of breastfeeding should be considered along with the mother’s clinical need for Altreno and any potential adverse effects on the breastfed child from Altreno.

To report suspected adverse reactions, contact Customer Service at 1-800-321-4576 or the FDA at 1-800-FDA-1088 or fda.gov/medwatch.

Please click here for full Prescribing Information.

The new 20g size is now available for only $60. Prescribe today.

A difference your patients can feel

Altreno named a top skincare product of 2020 by Shape Magazine!

Proven
inflammatory
lesion reductions

Primary Endpoints^1,2

Trial 1

Trial 2

Significant inflammatory lesion reductions at Week 12^1,2

Proven
comedonal
lesion reductions

Primary Endpoints^1,2

Trial 1

Trial 2

Significant comedonal lesion reductions at week 12

Actual patients from Trial 1 after 12 weeks of once-daily Altreno Lotion treatment.

A lotion formulated
with hydrating
ingredients for
your patients.

“This product
absorbs quickly”

“I see an
improvement in skin
smoothness”

Strong is the
new smooth

Adverse events
reported in ≥1% of
patients and more
frequently than
Vehicle².

Patient benefits

Altreno Lotion can be applied at any time — day or night, once daily. It can even be worn under makeup.⁶ It’s ideal for active and successful women who favor premium products.

Over

97%

of physicians agreed that
the lotion vehicle:

For healthcare
professionals

The new 20g size is now available for only $60. Prescribe today.

A difference your patients can feel

Altreno named a top skincare product of 2020 by Shape Magazine!

Proven inflammatory lesion reductions

Primary Endpoints1,2

Trial 1

Trial 2

Significant inflammatory lesion reductions at Week 121,2

Proven comedonal lesion reductions

Primary Endpoints1,2

Trial 1

Trial 2

Significant comedonal lesion reductions at week 12

Actual patients from Trial 1 after 12 weeks of once-daily Altreno Lotion treatment.

A lotion formulated with hydrating ingredients for your patients.

“This product absorbs quickly”

“I see an improvement in skin smoothness”

Strong is the new smooth

Adverse events reported in ≥1% of patients and more frequently than Vehicle2.

Patient benefits

Altreno Lotion can be applied at any time — day or night, once daily. It can even be worn under makeup.6 It’s ideal for active and successful women who favor premium products.

Over

97%

of physicians agreed that the lotion vehicle:

For healthcare professionals

Proven
inflammatory
lesion reductions

Primary Endpoints^1,2

Significant inflammatory lesion reductions at Week 12^1,2

Proven
comedonal
lesion reductions

Primary Endpoints^1,2

A lotion formulated
with hydrating
ingredients for
your patients.

“This product
absorbs quickly”

“I see an
improvement in skin
smoothness”

Strong is the
new smooth

Adverse events
reported in ≥1% of
patients and more
frequently than
Vehicle².

Altreno Lotion can be applied at any time — day or night, once daily. It can even be worn under makeup.⁶ It’s ideal for active and successful women who favor premium products.

of physicians agreed that
the lotion vehicle:

For healthcare
professionals